{"id":9750,"date":"2024-10-22T13:47:55","date_gmt":"2024-10-22T05:47:55","guid":{"rendered":"https:\/\/sklmo.tsinghua.edu.cn\/?p=9750"},"modified":"2024-10-22T13:47:56","modified_gmt":"2024-10-22T05:47:56","slug":"%e9%83%91%e6%92%bc%e7%90%83%e5%9b%a2%e9%98%9f%e5%90%88%e4%bd%9c%e6%8f%ad%e7%a4%ba%e6%b7%8b%e5%b7%b4%e6%af%92%e7%b4%a0-%ce%b2%e5%8d%8f%e5%8a%a9%e7%99%8c%e7%97%87%e9%aa%a8%e8%bd%ac%e7%a7%bb%e7%9a%84","status":"publish","type":"post","link":"https:\/\/sklmo.tsinghua.edu.cn\/?p=9750","title":{"rendered":"\u90d1\u64bc\u7403\u56e2\u961f\u5408\u4f5c\u63ed\u793a\u6dcb\u5df4\u6bd2\u7d20-\u03b2\u534f\u52a9\u764c\u75c7\u9aa8\u8f6c\u79fb\u7684\u5b9a\u690d\u548c\u6eb6\u9aa8\u6027\u751f\u957f"},"content":{"rendered":"\n

\u9aa8\u8f6c\u79fb\u662f\u4e73\u817a\u764c\u5e38\u89c1\u5e76\u53d1\u75c7\uff0c\u8d85\u8fc770%\u60a3\u8005\u4f1a\u53d1\u751f\u9aa8\u8f6c\u79fb\u30101\u3011\u3002\u9aa8\u8f6c\u79fb\u4ecd\u7136\u662f\u4e73\u817a\u764c\u6cbb\u7597\u7684\u91cd\u8981\u6311\u6218\uff0c\u5e76\u901a\u5e38\u5728\u521d\u59cb\u6cbb\u7597\u591a\u5e74\u540e\u51fa\u73b0\u3002\u9aa8\u8f6c\u79fb\u7814\u7a76\u7684\u4e00\u4e2a\u91cd\u8981\u95ee\u9898\u662f\u80bf\u7624\u7ec6\u80de\u5982\u4f55\u5728\u9aa8\u5fae\u73af\u5883\u4e2d\u751f\u5b58\u548c\u589e\u6b96\uff0c\u5982\u4f55\u4ece\u201c\u4f11\u7720\u201d\u72b6\u6001\u8f6c\u53d8\u4e3a\u201c\u6d3b\u8dc3\u201d\u6eb6\u9aa8\u6027\u9aa8\u8f6c\u79fb\u72b6\u6001\u30102\u3011\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u6d89\u53ca\u80bf\u7624\u7ec6\u80de\u4e0e\u9aa8\u57fa\u8d28\u7ec6\u80de\u4e4b\u95f4\u590d\u6742\u76f8\u4e92\u4f5c\u7528\uff0c\u7531\u5c1a\u672a\u5b8c\u5168\u7406\u89e3\u7684\u590d\u6742\u4fe1\u53f7\u901a\u8def\u4ecb\u5bfc\u30103\u3011\u3002\u57fa\u4e8e\u4f53\u5916\u57fa\u56e0\u8868\u8fbe\u5206\u6790\u548c\u5019\u9009\u57fa\u56e0\u9a8c\u8bc1\u7684\u7814\u7a76\u5df2\u7ecf\u9274\u5b9a\u4e86\u4e00\u4e9b\u4fc3\u8fdb\u9aa8\u8f6c\u79fb\u7684\u57fa\u56e0\u30104-6\u3011\u3002\u7136\u800c\uff0c\u4f53\u5916\u57f9\u517b\u7684\u80bf\u7624\u7ec6\u80de\u4e0e\u4f53\u5185\u9aa8\u5fae\u73af\u5883\u4e2d\u7684\u80bf\u7624\u7ec6\u80de\u5728\u57fa\u56e0\u8868\u8fbe\u4e0a\u53ef\u80fd\u5b58\u5728\u5de8\u5927\u5dee\u5f02\u3002\u56e0\u6b64\uff0c\u4e4b\u524d\u7684\u7814\u7a76\u53ef\u80fd\u9057\u6f0f\u4e86\u4e00\u4e9b\u5173\u952e\u7684\u9aa8\u8f6c\u79fb\u57fa\u56e0\u3002\u5728\u9aa8\u5fae\u73af\u5883\u4e2d\u6210\u529f\u5b9a\u690d\u7684\u80bf\u7624\u7ec6\u80de\u6570\u91cf\u975e\u5e38\u6709\u9650\uff0c\u8fd9\u4e9b\u7a00\u6709\u80bf\u7624\u7ec6\u80de\u5728\u5176\u539f\u4f4d\u72b6\u6001\u4e0b\u7684\u8f6c\u5f55\u7ec4\u7279\u5f81\u5c1a\u672a\u88ab\u7814\u7a76\u3002<\/p>\n\n\n\n

2024\u5e748\u670815\u65e5\uff0c\u6e05\u534e\u5927\u5b66\u57fa\u7840\u533b\u5b66\u9662\u3001\u5206\u5b50\u80bf\u7624\u5b66\u5168\u56fd\u91cd\u70b9\u5b9e\u9a8c\u5ba4\uff08\u6e05\u534e\uff09\u90d1\u64bc\u7403\u56e2\u961f\u548c\u9752\u5c9b\u5927\u5b66\u9644\u5c5e\u533b\u9662\u5cb3\u658c\u56e2\u961f\u5408\u4f5c\u5728Nature Cell Biology\u671f\u520a\u4e0a\u53d1\u8868\u4e86\u9898\u4e3aLymphotoxin-\u03b2 promotes breast cancer bone metastasis colonization and osteolytic outgrowth<\/em>\u7684\u7814\u7a76\u8bba\u6587\u3002\u6742\u5fd7\u7f16\u8f91\u90e8\u4e5f\u5c06\u4e3a\u8be5\u8bba\u6587\u914d\u53d1Research briefing\u7684\u4eae\u70b9\u6587\u7ae0\u63a8\u8350\u3002\u5728\u672c\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u5bf9\u9aa8\u8f6c\u79fb\u65e9\u671f\u5b9a\u690d\u80bf\u7624\u7ec6\u80de\u7684\u5355\u7ec6\u80deRNA-Seq\u5206\u6790\u53ca\u4f53\u5185\u7b5b\u9009\uff0c\u9274\u5b9a\u4e86\u6dcb\u5df4\u6bd2\u7d20-\u03b2\uff08Lymphotoxin-\u03b2\uff0cLT\u03b2\uff09\u5728\u4fc3\u8fdb\u4e73\u817a\u764c\u9aa8\u8f6c\u79fb\u5b9a\u690d\u548c\u8fdb\u5c55\u7684\u5173\u952e\u4f5c\u7528\u3002<\/p>\n\n\n\n

\"\"
\u6dcb\u5df4\u6bd2\u7d20-\u03b2\u534f\u52a9\u764c\u75c7\u9aa8\u8f6c\u79fb\u7684\u5b9a\u690d\u548c\u6eb6\u9aa8\u6027\u751f\u957f<\/figcaption><\/figure>\n\n\n\n

\u4e3a\u63a2\u7a76\u9aa8\u8f6c\u79fb\u65e9\u671f\u5b9a\u690d\u9636\u6bb5\u7a00\u6709\u80bf\u7624\u7ec6\u80de\u5728\u5176\u539f\u4f4d\u72b6\u6001\u4e0b\u7684\u7279\u5f81\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\uff08single cell RNA sequencing\uff0cscRNA-Seq\uff09\u5206\u6790\u4e86\u5c0f\u9f20\u9aa8\u8f6c\u79fb\u6a21\u578b\u4e0d\u540c\u9636\u6bb5\u80bf\u7624\u7ec6\u80de\u7684\u8f6c\u5f55\u7ec4\u7279\u5f81\u3002\u968f\u540e\uff0c\u6784\u5efa\u4e86\u9aa8\u8f6c\u79fb\u80bf\u7624\u7ec6\u80de\u9ad8\u8868\u8fbe\u7684\u5305\u542b\u819c\u86cb\u767d\u548c\u5206\u6ccc\u86cb\u767d\u7684\u5c0f\u578bcDNA\u8fc7\u8868\u8fbe\u6587\u5e93\uff0c\u5e76\u8fdb\u884c\u4e86\u4f53\u5185\u9aa8\u8f6c\u79fb\u5b9e\u9a8c\u7684\u7b5b\u9009\u3002\u7ed3\u679c\u8868\u660e\uff0cLT\u03b2\u4e0d\u4ec5\u662f\u4fc3\u8fdb\u8f6c\u79fb\u5b9a\u690d\u7684\u5173\u952e\u56e0\u7d20\uff0c\u8fd8\u4fc3\u8fdb\u6eb6\u9aa8\u6027\u9aa8\u8f6c\u79fb\u7684\u8fdb\u5c55\u3002<\/p>\n\n\n\n

\u5728\u4e73\u817a\u764c\u60a3\u8005\u4e2d\uff0cLT\u03b2\u9ad8\u8868\u8fbe\u4e0e\u9aa8\u8f6c\u79fb\u53d1\u751f\u6210\u6b63\u76f8\u5173\u3002\u5355\u7ec6\u80de\u6d4b\u5e8f\u5206\u6790\u663e\u793a\uff0c\u9aa8\u5fae\u73af\u5883\u80bf\u7624\u7ec6\u80de\u4e2dLT\u03b2\u7684\u8868\u8fbe\u663e\u8457\u9ad8\u4e8e\u4f53\u5916\u57f9\u517b\u6216\u8005\u539f\u4f4d\u72b6\u6001\u4e0b\u80bf\u7624\u7ec6\u80de\u5185LT\u03b2\u7684\u8868\u8fbe\u3002\u5e76\u4e14\u8fd9\u79cd\u9ad8\u8868\u8fbe\u53ef\u80fd\u662f\u7531\u4e8e\u6210\u9aa8\u7ec6\u80de\u5206\u6ccc\u7684RANKL\u6240\u8bf1\u5bfc\u3002\u5728\u591a\u79cd\u6a21\u578b\u4e2d\u8bc1\u5b9e\uff0c\u963b\u65adLT\u03b2\u663e\u793a\u964d\u4f4e\u9aa8\u8f6c\u79fb\u3002\u7279\u522b\u662f\u5728\u5f88\u591a\u4e4b\u524d\u62a5\u9053\u7684\u9aa8\u8f6c\u79fb\u4f11\u7720\u7ec6\u80de\u7684\u6a21\u578b\u4e0a\uff0cLT\u03b2\u7684\u8868\u8fbe\u6fc0\u6d3b\u4e86\u8fd9\u4e9b\u4f11\u7720\u80bf\u7624\u7ec6\u80de\uff0c\u4fc3\u8fdb\u764c\u7ec6\u80de\u7684\u9aa8\u7ec4\u7ec7\u5b9a\u690d\uff0c\u5e76\u5e2e\u52a9\u5f62\u6210\u665a\u671f\u6eb6\u9aa8\u6027\u9aa8\u8f6c\u79fb\u75c5\u7076\u3002<\/p>\n\n\n\n

\u5728\u673a\u5236\u4e0a\uff0c\u5f53\u80bf\u7624\u7ec6\u80de\u5230\u8fbe\u9aa8\u5fae\u73af\u5883\u65f6\uff0c\u9aa8\u5fae\u73af\u5883\u4e2d\u7684RANKL \uff08\u6838\u56e0\u5b50\u03baB\u53d7\u4f53\u6d3b\u5316\u56e0\u5b50\u914d\u4f53\uff09\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80deLT\u03b2\u7684\u8868\u8fbe\u3002LT\u03b2\u4e0e\u6210\u9aa8\u7ec6\u80de\u8868\u9762\u7684LT\u03b2\u53d7\u4f53\uff08LT\u03b2R\uff09\u7ed3\u5408\uff0c\u4e00\u65b9\u9762\u4ecb\u5bfc\u80bf\u7624\u7ec6\u80de\u5728\u9aa8\u5fae\u73af\u5883\u7684\u5b9a\u690d\uff0c\u53e6\u4e00\u65b9\u9762\u523a\u6fc0\u6210\u9aa8\u7ec6\u80de\u5185NF-\u03baB2\u4fe1\u53f7\u901a\u8def\u6fc0\u6d3b\uff0c\u8fdb\u800c\u8bf1\u5bfc\u8d8b\u5316\u56e0\u5b50\uff08CCL2\u548cCCL5\uff09\u7684\u4ea7\u751f\u3002CCL2\u548cCCL5\u901a\u8fc7\u53cd\u9988\u62db\u52df\u5de8\u566c\u7ec6\u80de\u5e76\u589e\u5f3a\u7834\u9aa8\u7ec6\u80de\u5206\u5316\u3002\u8fd9\u4e9b\u4f5c\u7528\u6709\u52a9\u4e8e\u80bf\u7624\u7ec6\u80de\u9aa8\u7ec4\u7ec7\u7684\u5b9a\u690d\uff0c\u4f11\u7720\u80bf\u7624\u7ec6\u80de\u91cd\u65b0\u6fc0\u6d3b\uff0c\u4ee5\u53ca\u6eb6\u9aa8\u6027\u9aa8\u8f6c\u79fb\u7684\u8fdb\u5c55\u3002<\/p>\n\n\n\n

\u6e05\u534e\u5927\u5b66\u57fa\u7840\u533b\u5b66\u9662\u3001\u5206\u5b50\u80bf\u7624\u5b66\u5168\u56fd\u91cd\u70b9\u5b9e\u9a8c\u5ba4\uff08\u6e05\u534e\uff09\u3001\u5c71\u897f\u533b\u79d1\u5927\u5b66-\u6e05\u534e\u5927\u5b66\u533b\u5b66\u9662\u524d\u6cbf\u533b\u5b66\u534f\u540c\u521b\u65b0\u4e2d\u5fc3\u7684\u90d1\u64bc\u7403\u526f\u6559\u6388\u662f\u8bba\u6587\u901a\u8baf\u4f5c\u8005\uff08Lead-corresponding author\uff09\uff0c\u9752\u5c9b\u5927\u5b66\u9644\u5c5e\u533b\u9662\u5cb3\u658c\u6559\u6388\u662f\u8bba\u6587\u7684\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff08Co-corresponding author\uff09\u3002\u90d1\u64bc\u7403\u5b9e\u9a8c\u5ba4\u535a\u58eb\u540e\u738b\u65ed\u7965\u3001\u5df2\u6bd5\u4e1aPTN\u535a\u58eb\u751f\u5f20\u817e\u6c5f\u53ca\u9752\u5c9b\u5927\u5b66\u9644\u5c5e\u533b\u9662\u90d1\u70b3\u946b\u533b\u5e08\u4e3a\u672c\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002\u6e05\u534e\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u738b\u5efa\u658c\u526f\u6559\u6388\u3001\u6e05\u534e\u5927\u5b66\u57fa\u7840\u533b\u5b66\u9662\u3001\u5206\u5b50\u80bf\u7624\u5b66\u5168\u56fd\u91cd\u70b9\u5b9e\u9a8c\u5ba4\uff08\u6e05\u534e\uff09\u84dd\u52cb\u526f\u6559\u6388\u3001\u6f58\u767b\u526f\u6559\u6388\u3001\u5085\u9633\u5fc3\u6559\u6388\u56e2\u961f\u4e3a\u8be5\u7814\u7a76\u63d0\u4f9b\u4e86\u6570\u636e\u5206\u6790\u3001\u6280\u672f\u6307\u5bfc\u548c\u5173\u952e\u8bd5\u5242\u7b49\u5e2e\u52a9\u3002\u8be5\u7814\u7a76\u5f97\u5230\u4e86\u6e05\u534e\u5927\u5b66\u5b9e\u9a8c\u52a8\u7269\u4e2d\u5fc3\u3001\u6e05\u534e\u5927\u5b66\u86cb\u767d\u8d28\u7814\u7a76\u6280\u672f\u4e2d\u5fc3\u7684\u5927\u529b\u652f\u6301\uff0c\u4ee5\u53ca\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u6e05\u534e-\u5317\u5927\u751f\u547d\u79d1\u5b66\u8054\u5408\u4e2d\u5fc3\uff08\u4f18\u79c0\u535a\u58eb\u540e\u57fa\u91d1\uff09\u548c\u6e05\u534e\u5927\u5b66\u81ea\u4e3b\u79d1\u7814\u8ba1\u5212\u7ecf\u8d39\u652f\u6301\u3002<\/p>\n\n\n\n

\u539f\u6587\u94fe\u63a5\uff1a<\/strong><\/p>\n\n\n\n

https:\/\/www.nature.com\/articles\/s41556-024-01478-9<\/a><\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n\n\n\n

1. Esposito, M., Guise, T. & Kang, Y. The biology of bone metastasis. Cold Spring Harb. Perspect. Med. 8, a031252. (2018).<\/p>\n\n\n\n

2. Sosa, M. S., Bragado, P. & Aguirre-Ghiso, J. A. Mechanisms of disseminated cancer cell dor-mancy: an awakening field. Nat. Rev. Cancer 14, 611-622 (2014).<\/p>\n\n\n\n

3. Satcher, R. L. & Zhang, X. H. Evolving can-cer-niche interactions and therapeutic targets during bone metastasis. Nat. Rev. Cancer 22, 85-101 (2022).<\/p>\n\n\n\n

4. Kang, Y. et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3, 537-549 (2003).<\/p>\n\n\n\n

5. Wang, H. et al. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell 27, 193-210 (2015).<\/p>\n\n\n\n

6. Lu, X. et al. VCAM-1 promotes osteolytic expan-sion of indolent bone micrometastasis of breast cancer by engaging alpha4beta1-positive osteo-clast progenitors. Cancer Cell 20, 701-714 (2011)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u9aa8\u8f6c\u79fb\u662f\u4e73\u817a\u764c\u5e38\u89c1\u5e76\u53d1\u75c7\uff0c\u8d85\u8fc770%\u60a3\u8005\u4f1a\u53d1\u751f\u9aa8\u8f6c\u79fb\u30101\u3011\u3002 […]<\/p>\n","protected":false},"author":1,"featured_media":9751,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23],"tags":[],"class_list":["post-9750","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-keyan"],"_links":{"self":[{"href":"https:\/\/sklmo.tsinghua.edu.cn\/index.php?rest_route=\/wp\/v2\/posts\/9750","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sklmo.tsinghua.edu.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sklmo.tsinghua.edu.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sklmo.tsinghua.edu.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sklmo.tsinghua.edu.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9750"}],"version-history":[{"count":1,"href":"https:\/\/sklmo.tsinghua.edu.cn\/index.php?rest_route=\/wp\/v2\/posts\/9750\/revisions"}],"predecessor-version":[{"id":9752,"href":"https:\/\/sklmo.tsinghua.edu.cn\/index.php?rest_route=\/wp\/v2\/posts\/9750\/revisions\/9752"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sklmo.tsinghua.edu.cn\/index.php?rest_route=\/wp\/v2\/media\/9751"}],"wp:attachment":[{"href":"https:\/\/sklmo.tsinghua.edu.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sklmo.tsinghua.edu.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sklmo.tsinghua.edu.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}