教育背景
2000-2005 四川大学华西医学院，临床医学学士
2005-2010 北京协和医学院，免疫学博士
工作经历
2010-2014 美国纪念斯隆-凯特琳癌症中心 博士后
2014-2017 美国纪念斯隆-凯特琳癌症中心 副研究员
2017-2023 清华大学医学院 助理教授
2023-2024 清华大学医学院 副教授
2024-至今 清华大学基础医学院 长聘副教授
研究领域
T淋巴细胞在抗感染和抗肿瘤中发挥核心作用。T细胞异常也是自身免疫和炎症性疾病的关键致病因素。T细胞也是免疫治疗的关键细胞，PD-1拮抗剂和CAR-T等新兴的免疫疗法都是对T细胞的干预和改造。本实验室长期研究T细胞基本生物学问题，包括激活、增殖、分化和记忆等过程的关键调控过程和因子，包括表冠遗传、转录、代谢因素等。基于这些基础研究，我们积极开发基于T细胞的各种全新疗法。近期，本实验室诱导出了一种全新的T细胞状态，命名为“类永生化功能性T细胞”（Immortal-like and Functional T cells，简称TIF），TIF具备类似于iPSC那样接近于无限的自我更新能力，同时完整保留了T细胞的生理功能，代表了一种新的哺乳动物细胞存在形式，解决了治疗性T细胞在体内持久性不足的关键问题。除了在肿瘤治疗中表现优异以外，基于TIF的T细胞还对各种常见非肿瘤慢性疾病，如哮喘、类风湿性关节炎等具有治愈潜力。彭敏实验室将进一步探索基于T细胞的免疫疗法对常见疾病的治愈潜力，同时开发全新的技术平台以大幅度降低细胞疗法的成本，期望最终实现对多种常见疾病的彻底治愈，实现医学史上的突破。
科学贡献
彭敏博士博士后期间发现并阐明mTORC1负向调节因子Sestrin和SZT2及其分子机制，发现代谢、表冠遗传和T细胞分化的联系，相关成果以第一作者身份发表在Cell (2014)、Science (2016)及Nature (2017)等期刊 。2017年, 彭敏博士入职清华大学开展独立科研和教学工作，致力于探索免疫学基本问题,尤其是记忆免疫记忆的本质及其操控。自实验室建立以来, 发现了T细胞新型钙离子通道，诱导出全新类永生化功能性T细胞(TIF)，并首次通过细胞疗法在动物模型中治愈哮喘，以通讯作者身份在Nature Immunol (2024), J Exp Med (2023, 2024), J Clin Invest (2022)及Cell Reports (2021) 等期刊发表多项研究成果。
荣誉奖励
2019 求是杰出青年学者奖
2018 拜耳研究员奖
2018 国家高层次人才青年项目
2015 纪念斯隆凯特琳癌症中心博士后研究奖
代表性论文
1.Gang Jin#, Yanyan Liu#, Lixia Wang, Zihao He, Xiaocui Zhao, Yuying Ma, Yuting Jia, Zhuoyang Li, Na Yin, Min Peng* . A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice. Nat Immunol. 2024. 2024. Jun;25(6):1059-1072.
Previewed by Nicholas Restifo and Luca Gattinoni in J Exp Med, “Synthetic soldiers: Turning T cells into immortal warriors”.
Highlighted by Yvonne Bordon in Nat Rev Immunol and Nat Rev Drug Discov, “CAR T cells take to the airways”.
2.Qing Shang,Zhuoyang Li, Na Yin, Min Peng*. Reconciling host-microbiota metabolic incompatibility safeguards male fertility. hlife. 2024;2:284–295
3.Lixia Wang#, Gang Jin#,Qiuping Zhou#, Yanyan Liu, Xiaocui Zhao, Zhuoyang Li, Na Yin, Min Peng*. Induction of immortal-like and functional CAR T cells by defined factors. J Exp Med. 2024 May 6;221(5):e20232368.
Previewed by Nicholas Restifo and Luca Gattinoni in J Exp Med, “Synthetic soldiers: Turning T cells into immortal warriors”.
4.Ying Liu#, Yuying Ma#, Jing Xu#, Guangyue Zhang#, Xiaocui Zhao#, Zihao He, Lixia Wang, Na Yin, Min Peng*. VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival. J Exp Med. 2023 Jun 5;220(6):e20221068.
5.Min Peng*, Ming O. Li*. Metabolism along the life journey of T cells. Life Metabolism. 2023, 002(001)
6.Na Yin#, Gang Jin#, Yuying Ma, Hanfei Zhao, Guangyue Zhang, Ming O. Li, Min Peng*. SZT2 maintains hematopoietic stem cell homeostasis via nutrient-mediated mTORC1 regulation. J Clin Invest., 2022 Oct 17, 130(20):e146272.
7.Hanfei Zhao, Ying Liu, Lixia Wang, Gang Jin, Xiaocui Zhao, Jing Xu, Guangyue Zhang, Yuying Ma, Na Yin, Min Peng*. Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity. Cell Reports. 2021 Dec 7;37(10):110083.
8.Ke Xu#, Na Yin#, Min Peng, Efstathios G Stamatiades, Sagar Chhangawala, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Kristelle J Capistrano, Chun Chou, Christina S Leslie, Ming O Li. Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses. Immunity. 2021. 54(5):976-87.
9.Ke Xu, Na Yin, Min Peng, Efstathios G Stamatiades, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Zhaoquan Wang, Kristelle J Capistrano, Chun Chou, Andrew G Levine, Alexander Y Rudensky, Ming O Li. Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science. 2021. Jan 22;371(6527):405-10.
10.Mytrang H. Do, Xinxin Wang, Xian Zhang, Chun Chou, Briana G. Nixon, Kristelle J. Capistrano, Min Peng, Alejo Efeyan, David M. Sabatini, Ming O. Li. Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance. J Exp Med. 2020 Jan 6;217(1):e20190848.
11.Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437.
12.Min Peng#, Na Yin#, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science, 2016 Oct 28; 354(6311): 481-484. (#equal contribution)
Preview in Science, 2016 Oct 28; 354(6311): 419-420. “Warburg meets epigenetics”.
Preview in Dev Cell, 2016 November 7;39: 286-287. “Metabolic Control of Cellular Differentiation”.
Preview in Cell Metab, 2016 November 8; 24: 651-652. “Metabolic Signaling Drives IFN-g”.
13.Jiangbin Ye, Wilhelm Palm, Min Peng, Bryan King, Tullia Lindsten, Ming O. Li, Constantinos Koumenis, Craig B. Thompson. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes Dev. 2015 Nov 15; 29 (22): 2331-6.
14.Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33.
Highlighted in Nat Rev Mol Cell Biol, 2014; 15: 701, “A RAG dissociation inhibitor”.
15.Weiming Ouyang, Will Liao, Chong T. Luo, Na Yin, Morgan Huse, Myoungjoo V. Kim, Min Peng, Pamela Chan, Qian Ma, Yifan Mo, Dies Meijer, Keji Zhao, Alexander Y. Rudensky, Gurinder Atwal, Michael Q. Zhang, Ming O. Li. Novel Foxo1-dependent transcriptional programs control Treg cell function. Nature. 2012 Nov 22; 491(7425): 554-9
16.Min Peng,Sha Guo,Na Yin, Jing Xue, Lian Shen, Qing Zhao, Wei Zhang. Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17. Immunology, 2010, 130(1): 83-91
17.Min Peng; Na Yin; Wei Zhang. Endocytosis of FcaR is clathrin and dynamin dependent but its cytoplasmic domain is not required. Cell Res, 2009, 20(2): 223-237
18.Na Yin; Min Peng; Yukun Xing; Wei Zhang. Intracellular pools of FcalphaR (CD89) in human neutrophils are localized in tertiary granules and secretory vesicles, and two FcalphaR isoforms are found in tertiary granules. J Leukoc Biol. 2007, 82: 551-558
Complete list of publications: https://orcid.org/0000-0002-5885-0660
