教育背景
2002-2007 北京大学基础医学院 医学学士
2007-2010 北京大学免疫学系 医学博士
工作经历：
2010-2015 美国芝加哥大学病理系 博士后
2015-2021 清华大学医学院 助理教授
2015-至今 清华大学免疫学研究所 研究员
2021-2024 清华大学医学院 副教授
2024-至今 清华大学基础医学院 副教授
研究领域
聚焦黏膜免疫与肠道菌群稳态，为炎症及抗肿瘤免疫治疗提供新思路。
肠道稳态失衡不仅增加肠道感染、炎症性肠病、食物过敏、肠道肿瘤等肠道疾病发生的风险，还与其他系统感染、癌症、肥胖、糖尿病、哮喘、关节炎、多发性硬化症、动脉粥样硬化、自闭症、抑郁症等多种全身性和肠外疾病密切相关。这些疾病基本包含了大部分的慢性疾病，不仅导致患者长期经受疾病折磨的痛苦，也给国家、社会和家庭带来巨大的医疗压力和经济负担。因此，肠道黏膜免疫是关乎国计民生的基础研究方向，是当前全球免疫学界研究的重点和热点。本实验室聚焦于天然淋巴样细胞的发育和功能机制，以及黏膜部位天然淋巴样细胞与其他细胞、食物、正常菌群以及病原菌之间的复杂的相互作用关系与分子机制，并进一步分析这些相互作用机制在感染、炎症、肿瘤、过敏、自身免疫、代谢性以及神经系统等疾病中发挥的作用。
科学贡献
研究主要聚焦于黏膜免疫与菌群稳态调控，尤其是天然淋巴样细胞（Innate lymphoid cells, ILCs）的黏膜功能与机制研究，为靶向黏膜免疫系统与肠道菌群从而治疗多种相关疾病提供了科学依据，已取得的学术成果包括：（1）黏膜免疫新作用与调控新机制：发现了ILCs在多种黏膜相关疾病中发挥的重要作用，发现黏膜免疫应答过程中多种细胞的互作与机制，鉴定了多种调控ILCs以及黏膜免疫应答的关键分子及通路，揭示了相关黏膜免疫细胞与人类疾病的重要关系；（2）菌群与免疫互作对机体疾病的影响：揭示黏膜免疫细胞影响菌群稳态的作用，发现菌群在疾病发生、发展与治疗中的重要作用与机制，探索了针对疾病的新的菌群干预手段。已在Cell Metabolism、Immunity、Nature Communications等杂志发表论文40多篇，引用超过3000次。
荣誉奖励
2023 《Mucosal Immunology》“Emerging leader in mucosal immunology”
2022 2021年Cell Press中国科学家最佳论文奖
2021 国家自然科学基金委优秀青年科学研究基金
2021 清华大学优秀博士论文导师
2020 北京免疫学会青年学者奖
2015 国际黏膜免疫学大会参会旅行奖
代表性论文
1.Panwei Song, Zhi Peng*, Xiaohuan Guo*. Gut microbial metabolites in cancer therapy. Trends in Endocrinology & Metabolism. (2024).
2.Jiacheng Hao, Chang Liu, Zhijie Gu, Xuanming Yang, Xun Lan, Xiaohuan Guo*. Dysregulation of Wnt/β-catenin Signaling Contributes to Intestinal Inflammation through Regulation of Group 3 Innate Lymphoid Cells. Nature Communications. (2024) 15, 2820.
3.Jiaoyan Huang, Xin Zhang, Hongkai Xu, Liuhui Fu, Yuke Liu, Jie Zhao, Jida Huang, Zuodong Song, Mingzhao Zhu, Yang-Xin Fu, Ye-Guang Chen, Xiaohuan Guo*. Intraepithelial Lymphocytes Promote Intestinal Regeneration through CD160/HVEM Signaling. Mucosal Immunology. (2024) 17 (2): 257-271.
4.Yi-tong Hu, Xing-zi Liu, Yue-miao Zhang*, Xiaohuan Guo*. The interaction network between group 3 innate lymphoid cells and other cells. Fundamental Research. In press.
5.Wenyan Wang, Na Li, Xiaohuan Guo*. The Crosstalk between ILC3s and Adaptive Immunity in Diseases. The FEBS Journal. (2023).
6.Xin Chen, Chengcheng Jin, Andrea Facciabene, Xiaohuan Guo, Yanbo Zhang. Editorial: Deciphering the Microbiome-Immunity-Cancer Axis. Frontiers in Immunology. (2022) 13: 897811.
7.Liuhui Fu, Jie Zhao, Jiaoyan Huang, Na Li, Xin Dong, Yao He, Wenyan Wang, Yu Wang, Ju Qiu, Xiaohuan Guo*. A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation. Journal of Allergy and Clinical Immunology. (2022) 149 (6): 2091-2104.
8.Jiaoyan Huang, Liuhui Fu, Jida Huang, Jie Zhao, Xin Zhang, Wenyan Wang, Yeyang Liu, Bowen Sun, Ju Qiu, Xiaoyu Hu, Zhihua Liu, Xiaohuan Guo*. Group 3 innate lymphoid cells protect the host from the uropathogenic Escherichia coli infection in the bladder. Advanced Science. (2022) 9: 2103303.
9.Yao He, Liuhui Fu, Yiping Li, Wenyan Wang, Mingli Gong, Jing Zhang, Xin Dong, Jiaoyan Huang, Quanbo Wang, Charles R. Mackay, Yang-Xin Fu, Yun Chen, Xiaohuan Guo*. Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity. Cell Metabolism. (2021) 33(5): 988–1000.
10.Wenyan Wang, Yan Xing, Yanmei Chang, Ying Wang, Yanxia You, Zekun Chen, Defu Ma*, Xiaomei Tong*, Xiaohuan Guo*. The Impaired Development of Innate Lymphoid Cells by Preterm Birth Is Associated with the Infant Disease. Science Bulletin. (2021) 66: 421-424.
11.Wenyan Wang*, Yiping Li, Xiaohuan Guo*. A Mouse Model of Citrobacter rodentium Oral Infection and Evaluation of Innate and Adaptive Immune Responses. STAR Protocols. (2020) 1(3):100218.
12.Wenyan Wang, Yiping Li, Jiacheng Hao, Yao He, Xin Dong, Yang-Xin Fu, Xiaohuan Guo*. The Interaction between Lymphoid Tissue Inducer-Like Cells and T Cells in the mLN Restrains Intestinal Humoral Immunity. Cell Reports. (2020) 32(3): 107936.
13.Xiaohuan Guo*, Yang-Xin Fu*. The tragic fate of group 3 innate lymphoid cells during HIV-1 infection. J Clin Invest (2015) 125(9):3430-2.
14.Xiaohuan Guo*, Yong Liang, Yuan Zhang, Anna Lasorella, Barbara L. Kee, Yang-Xin Fu*. Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2−Dependent Regulation of Microbiota. Immunity (2015) 42(1): 731–743.
15.Xiaohuan Guo, Ju Qiu, Tony Tu, Xuanming Yang, Liufu Deng, Robert A. Anders, Liang Zhou, and Yang-Xin Fu. Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection. Immunity (2014) 40(1): 25–39.
(*, corresponding author; #, co-first Author)
